Razib Khan One-stop-shopping for all of my content

July 3, 2011

Any Tutsi genotypes around?

Filed under: African Ancestry Project,Genetics,Genomics — Razib Khan @ 11:05 am

If anyone has, or knows of, Tutsi genotypes that I could analyze for the African Ancestry Project, could you please email me at africanancestryproject-at-gmail-dot-com? I want to ascertain the extent of genetic differences between Tutsi and Bantu populations, and whether the source of the Tutsi were Nilotic or Cushitic.

May 2, 2011

ADMIXTURE, African Ancestry Project, and confirmation bias

I’ve been running the African Ancestry Project for a while now on the side on Facebook. But it’s getting unwieldy, so I finally set up the website. The main reason I started it up is that there have been complaints for a while now of problems with the 23andMe “ancestry painting” and such for some African groups. For example, a Nubian might be 70% “European.” One might argue that this is due to Arab admixture, but this is clearly not so if you look at the PCA plot. What’s going on? Probably a problem with the reference populations (only Yoruba for Africa), ascertainment bias in the chip (they’re tuned to European variation), and the fact that African genetic variance can cause some issues. I don’t know. But the problem has been persistent, and since most of the other genome blogging projects exclude Africans because they’re so genetically diverse I decided to take it on.

Three groups of people have submitted:

- People of the African Diaspora in the New World

- People from Africa, disproportionately Northeast Africans (Horn of African + Nubia, etc.)

- People of some suspected or known minor component of African ancestry

I’m at ~70 participants now. As one reference ...

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