Category Archives: Polygenic Risk Score

Unless you have been sleeping under a rock you are aware that there are lots of constant discussions about “polygenic risk scores” (PRS) and residual “population stratification.” The basic issue here is that when you have a risk profile generated by lots of smaller genetic effects that you sum up together the inference of those […]

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A new “polygenic risk score” (PRS) paper is making some waves, Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood. Since it is open access I suggest you read it. But basically, they took ~2 million common variants (there are about ~100 million common variants in the world population) in ~300,000 individuals in […]

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  One of the things that is evident and the norm when you are interested in genetics and genomics is that things happen fast. There are some sciences which proceed at a normal and conventional pace. But, because genomics is fundamentally driven by the …

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Razib Khan