{"id":37104,"date":"2011-02-01T14:16:47","date_gmt":"2011-02-01T22:16:47","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=9590"},"modified":"2011-02-09T02:31:19","modified_gmt":"2011-02-09T10:31:19","slug":"a-genomic-map-of-human-variation-where-we%e2%80%99re-at","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2011\/02\/01\/a-genomic-map-of-human-variation-where-we%e2%80%99re-at\/","title":{"rendered":"A genomic map of human variation, where we\u2019re at"},"content":{"rendered":"

Zack has started exploring the K’s of his merged data set<\/a> for HAP. A commenter<\/a> suggests that:<\/p>\n

\n

As you have begun interpreting the reference results, let me make a friendly warning: you have to keep in mind that most of the reference populations of ethnic groups are extremely limited in sample size (with only between 2 and 25 individuals) and from very obscure sources, and you should keep away from drawing conclusions about millions of people based on such limited number of individuals.<\/p>\n<\/blockquote>\n

This seems a rather reasonable caution. But I don’t think such a vague piece of advice really adds any value. These sorts of caveats are contingent upon:<\/p>\n

– The scope of the question being asked (i.e., how fine a grain is the variation you are attempting to measure going to be)<\/p>\n

– The sample size<\/p>\n

– The representativeness<\/p>\n

– The thickness of the marker set (10 autosomal markers vs. 500,000 SNPs)<\/p>\n

\nThis isn’t a qualitative issue, easily to divide into “right” and “wrong.” Sometimes an N = 1 is very insightful. That’s why the whole genome of one<\/i> Bushman<\/a> was very useful. In fact, the whole genome of any<\/b> random Sub-Saharan African, and the whole genome of any<\/b> random non-African …<\/p>\n","protected":false},"excerpt":{"rendered":"

Zack has started exploring the K’s of his merged data set for HAP. A commenter suggests that:
\nAs you have begun interpreting the reference results, let me make a friendly warning: you have to keep in mind that most of the reference populations of…<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,82,998,568,360,209],"tags":[],"class_list":["post-37104","post","type-post","status-publish","format-standard","hentry","category-genetics","category-genomics","category-harappa-ancestry-project","category-human-variation","category-personal-genomics","category-population-substructure"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=37104"}],"version-history":[{"count":6,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37104\/revisions"}],"predecessor-version":[{"id":37466,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37104\/revisions\/37466"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=37104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=37104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=37104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}