{"id":37180,"date":"2011-02-03T13:54:41","date_gmt":"2011-02-03T21:54:41","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=9639"},"modified":"2011-02-10T01:17:08","modified_gmt":"2011-02-10T09:17:08","slug":"why-siblings-differ-differently","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2011\/02\/03\/why-siblings-differ-differently\/","title":{"rendered":"Why siblings differ differently"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2011\/02\/sib2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-9641\" src=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2011\/02\/sib2.png\" alt=\"\" width=\"350\" height=\"366\" \/><\/a><i><b>The Pith:<\/b> In this post I examine how looking at genomic data can clarify exactly how closely related siblings really are, instead of just assuming that they&#8217;re about 50% similar. I contrast this randomness among siblings to the hard &amp; fast deterministic nature of of parent-child inheritance. Additionally, I detail how the idealized spare concepts of genetics from 100 years ago are modified by what we now know about how genes are physically organized, and, reorganized. Finally, I explain how this clarification allows us to potentially understand with greater precision the nature of inheritance of complex traits which vary within families, and across the whole population.<\/i><\/p>\n<p>Humans are diploid organisms. We have two copies of each gene, inherited from each parent (the exception here is for males, who have only one X chromosome inherited from the mother, and lack many compensatory genes on the Y chromosome inherited from the father). Our own parents have two copies of each gene, one inherited from each of their parents. Therefore, one can model a grandchild from two pairs of grandparents as a mosaic of the genes of the four ancestral grandparents. <strong>But, the relationship between &#8230;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Pith: In this post I examine how looking at genomic data can clarify exactly how closely related siblings really are, instead of just assuming that they&#8217;re about 50% similar. I contrast this randomness among siblings to the hard &amp; fast de&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[157,1035,4,82,723,481,525,1036,1037,360,509,1038,1039],"tags":[],"class_list":["post-37180","post","type-post","status-publish","format-standard","hentry","category-23andme","category-family","category-genetics","category-genomics","category-heritability","category-human-genetics","category-human-genomics","category-human-quantitative-genetics","category-pedigrees","category-personal-genomics","category-quantitative-genetics","category-quantitative-genomics","category-siblings"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=37180"}],"version-history":[{"count":9,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37180\/revisions"}],"predecessor-version":[{"id":37514,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37180\/revisions\/37514"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=37180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=37180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=37180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}