{"id":37682,"date":"2011-02-14T15:38:01","date_gmt":"2011-02-14T23:38:01","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=9918"},"modified":"2011-02-23T10:33:37","modified_gmt":"2011-02-23T18:33:37","slug":"who-are-those-houston-gujus","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2011\/02\/14\/who-are-those-houston-gujus\/","title":{"rendered":"Who are those Houston Gujus?"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2011\/02\/guj1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-9919\" src=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2011\/02\/guj1.png\" alt=\"\" width=\"300\" height=\"262\" \/><\/a>The figure to the left is a three dimensional representation of principal components 1, 2, and 3, generated from a sample of Gujaratis from Houston, and Chinese from Denver. When these two populations are pooled together the Chinese form a very homogeneous cluster. They don&#8217;t vary much across the three top explanatory dimensions of genetic variance. In contrast, the Gujaratis <i>do<\/i> vary. This is not surprising. In the supplements of <a href=\"http:\/\/www.nature.com\/nature\/journal\/v461\/n7263\/full\/nature08365.html\">Reconstructing Indian population history<\/a> it was notable that the Gujaratis did tend to shake out into two distinct clusters in the PCAs. This is a finding you see over and over when you manipulate the HapMap Gujarati data set. In reality, there aren&#8217;t two equivalent clusters. Rather, there&#8217;s one &#8220;tight&#8221; cluster, which I will label &#8220;Gujarati_B&#8221; from now on in my data set, and another cluster, &#8220;Gujarati_A,&#8221; which really just consists of all the individuals who are outside of Gujarati_B cluster. Even when compared to other <a href=\"http:\/\/www.harappadna.org\/2011\/02\/south-asian-pca\/\">South Asian<\/a> populations these two distinct categories persist in the HapMap Gujaratis.<\/p>\n<p><a href=\"http:\/\/www.harappadna.org\/2011\/02\/hapmap-gujaratis\/\">Zack has already<\/a> identified a major difference between the two clusters: <b>Gujarat_A has some individuals with much more &#8220;West Eurasian&#8221; ancestry.<\/b> &#8230;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The figure to the left is a three dimensional representation of principal components 1, 2, and 3, generated from a sample of Gujaratis from Houston, and Chinese from Denver. When these two populations are pooled together the Chinese form a very homogen&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,4,82,1127,624,58,159,64,360],"tags":[],"class_list":["post-37682","post","type-post","status-publish","format-standard","hentry","category-culture","category-genetics","category-genomics","category-gujaratis","category-hapmap","category-health","category-medical-genetics","category-medicine","category-personal-genomics"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=37682"}],"version-history":[{"count":10,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37682\/revisions"}],"predecessor-version":[{"id":38001,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/37682\/revisions\/38001"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=37682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=37682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=37682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}