{"id":40253,"date":"2011-05-02T12:29:07","date_gmt":"2011-05-02T20:29:07","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=11419"},"modified":"2011-05-02T12:29:07","modified_gmt":"2011-05-02T20:29:07","slug":"admixture-african-ancestry-project-and-confirmation-bias","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2011\/05\/02\/admixture-african-ancestry-project-and-confirmation-bias\/","title":{"rendered":"ADMIXTURE, African Ancestry Project, and confirmation bias"},"content":{"rendered":"

I’ve been running the African Ancestry Project<\/a> for a while now on the side on Facebook. But it’s getting unwieldy, so I finally set up the website<\/a>. The main reason I started it up is that there have been complaints for a while now of problems with the 23andMe “ancestry painting” and such for some African groups. For example, a Nubian might be 70% “European.” One might argue that this is due to Arab admixture, but this is clearly not so if you look at the PCA plot. What’s going on? Probably a problem with the reference populations (only Yoruba for Africa), ascertainment bias in the chip (they’re tuned to European variation), and the fact that African genetic variance can cause some issues. I don’t know. But the problem has been persistent, and since most of the other genome blogging projects exclude Africans because they’re so genetically diverse I decided to take it on.<\/p>\n

Three groups of people have submitted:<\/p>\n

– People of the African Diaspora in the New World<\/p>\n

– People from Africa, disproportionately Northeast Africans (Horn of African + Nubia, etc.)<\/p>\n

– People of some suspected or known minor component of African ancestry<\/p>\n

I’m at ~70 participants now. As one reference …<\/p>\n","protected":false},"excerpt":{"rendered":"

I’ve been running the African Ancestry Project for a while now on the side on Facebook. But it’s getting unwieldy, so I finally set up the website. The main reason I started it up is that there have been complaints for a while now of proble…<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290,1296,1297,1298,4,82,77],"tags":[],"class_list":["post-40253","post","type-post","status-publish","format-standard","hentry","category-admixture","category-african-ancestry-project","category-bias","category-confirmation-bias","category-genetics","category-genomics","category-science"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/40253","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=40253"}],"version-history":[{"count":5,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/40253\/revisions"}],"predecessor-version":[{"id":40416,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/40253\/revisions\/40416"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=40253"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=40253"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=40253"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}