{"id":51899,"date":"2011-11-15T16:15:03","date_gmt":"2011-11-16T00:15:03","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=14515"},"modified":"2011-11-15T16:15:03","modified_gmt":"2011-11-16T00:15:03","slug":"sample-size-schample-size","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2011\/11\/15\/sample-size-schample-size\/","title":{"rendered":"Sample size, schample size"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.discovermagazine.com\/notrocketscience\/2011\/11\/15\/oxtr-gene-produces-differences-in-kind-behaviour-that-people-can-spot-in-20-seconds\/\">Ed Yong<\/a> has a post up on a behavior genetic <a href=\"http:\/\/www.pnas.org\/content\/early\/2011\/11\/08\/1112658108\">publication<\/a> where the sample size is 23. The researchers report a correlation between a <a href=\"http:\/\/www.snpedia.com\/index.php\/Rs53576\">SNP<\/a> on the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxytocin_receptor\">OXTR locus<\/a> and &#8220;prosociality.&#8221; To make a long story short the sample size suggested to <a href=\"http:\/\/www.genomesunzipped.org\/\">Dr. Daniel MacArthur and Dr. Jospeh Pickrell<\/a> that this was a spurious correlation. The bigger issue here is that there are functional reasons to assume that some genes are correlated with normal human variation in psychology and behavior, and a robust body of literature that these traits are heritable (trait value is highly predictive across relatives), <strong>but, the results associating a particular genetic marker with a given trait are much less robust.<\/strong><\/p>\n<p>But I immediately realized something interesting: a sample size of 23 may be small, but there is a sample size potentially of thousands! I know my genotype at this SNP from 23andMe. How about some 23andMe customers get together and produce some results, and then get published in <em>PNAS<\/em>? A sample size of 230 would be easy I think, and you could probably push it much closer to 1,000.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/GeneExpressionBlog\/~4\/_sXFYy1e7ps\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ed Yong has a post up on a behavior genetic publication where the sample size is 23. The researchers report a correlation between a SNP on the OXTR locus and &#8220;prosociality.&#8221; To make a long story short the sample size suggested to Dr. Daniel MacArthur and Dr. Jospeh Pickrell that this was a spurious correlation. [&#8230;]<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[85],"tags":[],"class_list":["post-51899","post","type-post","status-publish","format-standard","hentry","category-behavior-genetics"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/51899","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=51899"}],"version-history":[{"count":4,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/51899\/revisions"}],"predecessor-version":[{"id":52272,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/51899\/revisions\/52272"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=51899"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=51899"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=51899"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}