{"id":717,"date":"2010-02-08T11:22:00","date_gmt":"2010-02-08T19:22:00","guid":{"rendered":"tag:blogger.com,1999:blog-10083047.post-6291735389766897597"},"modified":"2010-02-08T11:25:24","modified_gmt":"2010-02-08T19:25:24","slug":"delayed-childbearing-autism","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2010\/02\/08\/delayed-childbearing-autism\/","title":{"rendered":"Delayed childbearing &amp; autism"},"content":{"rendered":"<p><a href=\"http:\/\/www3.interscience.wiley.com\/journal\/123275763\/abstract?CRETRY=1&#038;SRETRY=0\">Independent and dependent contributions of advanced maternal and paternal ages to autism risk<\/a>:<\/p>\n<blockquote><p> Reports on autism and parental age have yielded conflicting results on whether mothers, fathers, or both, contribute to increased risk. We analyzed restricted strata of parental age in a 10-year California birth cohort to determine the independent or dependent effect from each parent. Autism cases from California Department of Developmental Services records were linked to State birth files (1990-1999). Only singleton births with complete data on parental age and education were included (<em>n<\/em>=4,947,935, cases=12,159). In multivariate logistic regression models, advancing maternal age increased risk for autism monotonically regardless of the paternal age. Compared with mothers 25-29 years of age, the adjusted odds ratio (aOR) for mothers 40+ years was 1.51 (95% CI: 1.35-1.70), or compared with mothers &lt;25 years of age, aOR=1.77 (95% CI, 1.56-2.00). In contrast, autism risk was associated with advancing paternal age primarily among mothers &lt;30: aOR=1.59 (95% CI, 1.37-1.85) comparing fathers 40+ vs. 25-29 years of age. However, among mothers &gt;30, the aOR was 1.13 (95% CI, 1.01-1.27) for fathers 40+ vs. 25-29 years of age, almost identical to the aOR for fathers &lt;25 years. Based on the first examination of heterogeneity in parental age effects, it appears that women&#8217;s risk for delivering a child who develops autism increases throughout their reproductive years whereas father&#8217;s age confers increased risk for autism when mothers are &lt;30, but has little effect when mothers are past age 30. <b>We also calculated that the recent trend towards delayed childbearing contributed approximately a 4.6% increase in autism diagnoses in California over the decade.<\/b>  <\/p><\/blockquote>\n<p>See <a href=\"http:\/\/www.sciencedaily.com\/releases\/2010\/02\/100208102411.htm?utm_source=feedburner&#038;utm_medium=feed&#038;utm_campaign=Feed:+sciencedaily+(ScienceDaily:+Latest+Science+News)&#038;utm_content=Google+Reader\">ScienceDaily<\/a> for more detail.<\/p>\n<div class=\"blogger-post-footer\"><img width='1' height='1' src='https:\/\/blogger.googleusercontent.com\/tracker\/10083047-6291735389766897597?l=www.gnxp.com%2Fblog%2Findex.php' alt='' \/><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Independent and dependent contributions of advanced maternal and paternal ages to autism risk: Reports on autism and parental age have yielded conflicting results on whether mothers, fathers, or both, contribute to increased risk. We analyzed restricte&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"class_list":["post-717","post","type-post","status-publish","format-standard","hentry","category-autism"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/717","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=717"}],"version-history":[{"count":0,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/717\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=717"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=717"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=717"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}