{"id":72707,"date":"2012-07-19T23:10:11","date_gmt":"2012-07-20T07:10:11","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=17403"},"modified":"2012-07-19T23:10:11","modified_gmt":"2012-07-20T07:10:11","slug":"inbred-shorter-people","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2012\/07\/19\/inbred-shorter-people\/","title":{"rendered":"Inbred shorter people"},"content":{"rendered":"<p><a href=\"http:\/\/www.plosgenetics.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pgen.1002655?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+plosgenetics%2FNewArticles+%28Ambra+-+Genetics+New+Articles%29\">Evidence of Inbreeding Depression on Human Height<\/a>, a paper with over 1,000 authors! (I exaggerate) It&#8217;s interesting because it <strong>seems to establish that inbreeding does have a deleterious effect on traits whose genetic architecture is presumably polygenic and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Additive_genetic_effects\">additive<\/a>.<\/strong> Why is this theoretically important? Because <a href=\"http:\/\/en.wikipedia.org\/wiki\/Inbreeding_depression\">inbreeding depression<\/a> is often assumed to be driven by the exposure of rare recessive larger effect alleles, which recombine in near relations. Using tens of thousands of individuals from across a dozen European nations the authors found that there is a consistent relationship between inbreeding and reduction in height.<\/p>\n<p>As the authors note height is a convenient trait to explore. First, it&#8217;s highly <a href=\"http:\/\/en.wikipedia.org\/wiki\/Heritable\">heritable<\/a>. 80 to 90 percent of the variation in the population is explained by variation in genes. Second, it&#8217;s easy to measure. Also, implicit in the paper is the fact that in Europe today there is far less of a environmental effect on height (that&#8217;s why the heritability value is high). Even in poor European nations most people have enough to eat, so height is highly heritable, allowing for appropriate cross-national comparison.<\/p>\n<p>\n<strong>The simplest way to state their results is that all things being equal the offspring of two &#8230;<img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/GeneExpressionBlog\/~4\/XsmszzV4aDs\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Evidence of Inbreeding Depression on Human Height, a paper with over 1,000 authors! (I exaggerate) It&#8217;s interesting because it seems to establish that inbreeding does have a deleterious effect on traits whose genetic architecture is presumably po&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,82,508],"tags":[],"class_list":["post-72707","post","type-post","status-publish","format-standard","hentry","category-genetics","category-genomics","category-height"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=72707"}],"version-history":[{"count":6,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72707\/revisions"}],"predecessor-version":[{"id":72776,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72707\/revisions\/72776"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=72707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=72707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=72707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}