{"id":72731,"date":"2012-07-20T08:59:09","date_gmt":"2012-07-20T16:59:09","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=17415"},"modified":"2012-07-20T08:59:09","modified_gmt":"2012-07-20T16:59:09","slug":"ashkenazi-jews-are-not-inbred","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2012\/07\/20\/ashkenazi-jews-are-not-inbred\/","title":{"rendered":"Ashkenazi Jews are not inbred"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/07\/321px-Natalie_Portman_Cannes.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/07\/321px-Natalie_Portman_Cannes.jpg\" alt=\"\" title=\"321px-Natalie_Portman_Cannes\" width=\"321\" height=\"598\" class=\"alignleft size-full wp-image-17416\" \/><\/a><a href=\"http:\/\/www.nature.com\/nature\/journal\/v466\/n7303\/full\/nature09103.html\">Jews<\/a>, and <a href=\"http:\/\/www.nature.com\/nature\/journal\/v466\/n7303\/full\/nature09103.html\">Ashkenazi Jews in particular<\/a>, are very genetically distinctive. A short and sweet way to think about this population is that they&#8217;re a moderately recent admixture between a Middle Eastern population, and Western Europeans, which has been relatively isolated due to sociocultural forces. As far as their inbreeding, well, here&#8217;s one recent paper, <a href=\"http:\/\/www.pnas.org\/content\/107\/37\/16222.full\">Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population<\/a>: <i>To explore the amount of genetic variation within the AJ and European populations, we first measured the mean heterozygosity. Surprisingly, we found a higher level of heterozygosity among AJ individuals compared with Europeans&#8230;confirming speculation made in one recent report and a trend seen in another&#8230;Although this difference may appear small, it is highly statistically significant because of the large number of individuals and markers analyzed, even after pruning SNPs that are in high LD. <b>The higher diversity in the AJ population was paralleled by a lower inbreeding coefficient, F, indicating the AJ population is more outbred than Europeans, not inbred, as has long been assumed<\/b>&#8230;The greater genetic variation among the AJ population was further confirmed using a pairwise identity-by-state (IBS) permutation &#8230;<img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/GeneExpressionBlog\/~4\/yRavRWtR--E\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jews, and Ashkenazi Jews in particular, are very genetically distinctive. A short and sweet way to think about this population is that they&#8217;re a moderately recent admixture between a Middle Eastern population, and Western Europeans, which has bee&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2071,4,82,481,525,460],"tags":[],"class_list":["post-72731","post","type-post","status-publish","format-standard","hentry","category-ashkenazi-jews","category-genetics","category-genomics","category-human-genetics","category-human-genomics","category-inbreeding"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=72731"}],"version-history":[{"count":7,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72731\/revisions"}],"predecessor-version":[{"id":72802,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72731\/revisions\/72802"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=72731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=72731"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=72731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}