{"id":72749,"date":"2012-07-21T13:17:54","date_gmt":"2012-07-21T21:17:54","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=17421"},"modified":"2012-07-21T13:17:54","modified_gmt":"2012-07-21T21:17:54","slug":"ashkenazi-jews-are-not-inbred-2","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2012\/07\/21\/ashkenazi-jews-are-not-inbred-2\/","title":{"rendered":"Ashkenazi Jews are not inbred \u2013 2"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/07\/Lauren_bacall_promo_photo.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-17422\" title=\"Lauren_bacall_promo_photo\" src=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/07\/Lauren_bacall_promo_photo-225x300.jpg\" alt=\"\" width=\"225\" height=\"300\" \/><\/a>I know I excoriate readers of this weblog for being stupid, ignorant, or lazy. But this constant badgering does result in genuinely insightful and important comments precisely and carefully stated on occasion. I put up my <a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/2012\/07\/ashkenazi-jews-are-not-inbred\">previous post in haste<\/a>, and when I published it I wasn&#8217;t totally happy with the evidence from which the authors adduced that Ashkenazi Jews were not inbred. Here&#8217;s <a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/2012\/07\/ashkenazi-jews-are-not-inbred\/comment-page-1\/#comment-144296\">why<\/a>, from\u00a0the comments: <em>Doesn\u2019t identity-by-state permutations test reflect a counterbalance of admixture vs. inbredness + drift? Rather than just the degree of inbreeding? Since the population has strong admixture effects, a low IBS doesn\u2019t exclude strong inbreeding, does it?<\/em><\/p>\n<p>From my little personal experience IBS is not the best statistic from which to generalize widely, and can be highly misleading in admixed individuals, as implied by the commenter. First, since I&#8217;ve stated above that the Ashkenazi Jews <em>are<\/em> admixed, let me go into a tangent as to why Ashkenazi <em>are<\/em> admixed between a Middle Eastern and Western European population, as opposed to being a relatively unadmixed ancient Eastern Mediterranean group with affinities to both regions. The previous <a href=\"http:\/\/www.pnas.org\/content\/107\/37\/16222.full\">previous paper<\/a> found evidence of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Linkage_disequilibrium\">linkage &#8230;<img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/GeneExpressionBlog\/~4\/wGI2L59QUSU\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I know I excoriate readers of this weblog for being stupid, ignorant, or lazy. But this constant badgering does result in genuinely insightful and important comments precisely and carefully stated on occasion. I put up my previous post in haste, and wh&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2072,2071,4,82,33,375],"tags":[],"class_list":["post-72749","post","type-post","status-publish","format-standard","hentry","category-ashkenazi-jewish-genetics","category-ashkenazi-jews","category-genetics","category-genomics","category-jewish-genetics","category-jewish-genomics"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=72749"}],"version-history":[{"count":6,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72749\/revisions"}],"predecessor-version":[{"id":72840,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/72749\/revisions\/72840"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=72749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=72749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=72749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}