{"id":73746,"date":"2012-09-04T22:41:17","date_gmt":"2012-09-05T06:41:17","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=18159"},"modified":"2012-09-04T22:41:17","modified_gmt":"2012-09-05T06:41:17","slug":"me-my-0-55-brother-against-my-0-45-brother","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2012\/09\/04\/me-my-0-55-brother-against-my-0-45-brother\/","title":{"rendered":"Me &amp; my 0.55 brother against my 0.45 brother"},"content":{"rendered":"<p><a href=\"http:\/\/www.plosgenetics.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pgen.0020041\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-18160\" title=\"journal.pgen.0020041.g001\" src=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/09\/journal.pgen_.0020041.g001-286x300.png\" alt=\"\" width=\"286\" height=\"300\" \/><\/a>One of the more fascinating things about getting much of your child&#8217;s pedigree genotyped is that one can ascertain true relatedness to various relatives, rather than just expected relatedness. For example, 28% of her genome is identical by descent from my father, while 22% is from my mother. She is 26% identical by descent with one uncle, and 24% with another. More practically, <strong>the understanding of patterns realized and concrete genetic relatedness within families allows us another avenue into teasing apart heritability.<\/strong> Though this method has been around for more than half-a-decade, I find it curious that when I <a href=\"http:\/\/www.plosgenetics.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pgen.0020041\">post on it<\/a> some commenters immediately make objections to twin studies. Why? Because they assume that the analysis had to be a twin study because they don&#8217;t know of the genomic methodology!<\/p>\n<p>But on a broader evolutionary scale, does this matter? Two of my siblings have a relatedness of 41%. In other words, as you can see in the histogram there is a wide variation in relatedness. Might this perhaps impact social relations? One can imagine genetically more similar siblings aligning against those who are dissimilar. Or not. I am skeptical &#8230;<img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/GeneExpressionBlog\/~4\/SKYs3FjCi9A\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the more fascinating things about getting much of your child&#8217;s pedigree genotyped is that one can ascertain true relatedness to various relatives, rather than just expected relatedness. For example, 28% of her genome is identical by descen&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,723],"tags":[],"class_list":["post-73746","post","type-post","status-publish","format-standard","hentry","category-genetics","category-heritability"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/73746","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=73746"}],"version-history":[{"count":5,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/73746\/revisions"}],"predecessor-version":[{"id":73831,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/73746\/revisions\/73831"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=73746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=73746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=73746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}