{"id":74615,"date":"2012-10-21T21:29:36","date_gmt":"2012-10-22T05:29:36","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=18849"},"modified":"2012-10-21T21:29:36","modified_gmt":"2012-10-22T05:29:36","slug":"the-arcane-art-of-ancient-admixture","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2012\/10\/21\/the-arcane-art-of-ancient-admixture\/","title":{"rendered":"The arcane art of ancient admixture"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/10\/journal.pgen_.1002947.g001.jpg\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-18850\" title=\"journal.pgen.1002947.g001\" src=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/10\/journal.pgen_.1002947.g001.jpg\" alt=\"\" width=\"306\" height=\"346\" \/><\/a>I have mentioned the <em>PLoS Genetics<\/em> paper, <a href=\"http:\/\/www.plosgenetics.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pgen.1002947\">The Date of Interbreeding between Neandertals and Modern Humans<\/a>, before because a version of it was put up on <a href=\"http:\/\/arxiv.org\/abs\/1208.2238\">arXiv<\/a>. The final paper has a few additions. For example, it mentions the <a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/2012\/08\/neanderthal-admixture-the-ecology-of-academe\/\">generally panned<\/a>\u00a0(at least in the circles I run in)\u00a0<em>PNAS<\/em> paper which suggested that ancient population structure could produce the same patterns which were earlier used to infer admixture with Neandertals (the authors also point to <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22513287\">Yang et al.<\/a> as a support for the proposition of admixture rather than structure). The primary result, dating the admixture between Neandertals and anatomically modern humans ~40-80,000 years before the present, is reiterated.<\/p>\n<p>An interesting aspect is that their method is to utilize linkage disequilibrium (LD) decay. It&#8217;s interesting because tens of thousands of years is a hell of a long time to be able to detect an admixture event via LD! In particular because there&#8217;s likely a palimpsest effect where there are intervening admixtures and other assorted demographic events (e.g., bottlenecks and selective sweeps can also generate LD). So how&#8217;d they do it? Basically the authors figured out a way to &#8230;<img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/GeneExpressionBlog\/~4\/BsoS1ZyFd_Y\" height=\"1\" width=\"1\"\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I have mentioned the PLoS Genetics paper, The Date of Interbreeding between Neandertals and Modern Humans, before because a version of it was put up on arXiv. The final paper has a few additions. For example, it mentions the generally panned\u00a0(at leas&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9,30,481],"tags":[],"class_list":["post-74615","post","type-post","status-publish","format-standard","hentry","category-anthroplogy","category-human-evolution","category-human-genetics"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/74615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=74615"}],"version-history":[{"count":5,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/74615\/revisions"}],"predecessor-version":[{"id":74686,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/74615\/revisions\/74686"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=74615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=74615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=74615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}