{"id":74677,"date":"2012-10-27T18:09:20","date_gmt":"2012-10-28T02:09:20","guid":{"rendered":"http:\/\/blogs.discovermagazine.com\/gnxp\/?p=18890"},"modified":"2012-10-27T18:09:20","modified_gmt":"2012-10-28T02:09:20","slug":"a-golden-age-of-sibling-comparisons","status":"publish","type":"post","link":"https:\/\/www.razib.com\/wordpress\/2012\/10\/27\/a-golden-age-of-sibling-comparisons\/","title":{"rendered":"A golden age of sibling comparisons"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/10\/siblings.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18894\" title=\"siblings\" src=\"http:\/\/blogs.discovermagazine.com\/gnxp\/files\/2012\/10\/siblings.jpg\" alt=\"\" width=\"600\" height=\"628\" \/><\/a><\/p>\n<p><em><strong>Image credit:<\/strong> Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings<\/em><\/p>\n<p>I really love the paper <a href=\"http:\/\/www.plosgenetics.org\/article\/info%3Adoi\/10.1371\/journal.pgen.0020041\">Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings<\/a>. I first read it about six years ago. The result is rather straightforward, but the problem is empirically a moderately deep one. Modern analytic genetics as the fusion between Mendelism and biometrics began with R. A. Fisher&#8217;s <a href=\"http:\/\/en.wikipedia.org\/wiki\/The_Correlation_between_Relatives_on_the_Supposition_of_Mendelian_Inheritance\">The Correlation between Relatives on the Supposition of Mendelian Inheritance<\/a> in 1918. But note, that paper <strong><em>assumed<\/em> particular relatedness between relatives.<\/strong> As highlighted in the above paper the <strong>expected<\/strong> values for most categories of relatedness always had a variance component which was unaccounted for, and so reduced the power of the methodology to ascertain the extent of heritability. The relatedness you can expect between any two siblings is ~0.50, and that is also the average across all siblings. <strong>But the reality is that in most cases two given siblings will not share half their genes identical by descent.<\/strong><\/p>\n<p>\nBefore the genomic era the precise assessment of relatedness in a given case was laborious, if at all feasible. But not so today. Because modern &#8230;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Image credit: Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings<\/p>\n<p>I really love the paper Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full S&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[82,360],"tags":[],"class_list":["post-74677","post","type-post","status-publish","format-standard","hentry","category-genomics","category-personal-genomics"],"_links":{"self":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/74677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/comments?post=74677"}],"version-history":[{"count":8,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/74677\/revisions"}],"predecessor-version":[{"id":74701,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/posts\/74677\/revisions\/74701"}],"wp:attachment":[{"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/media?parent=74677"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/categories?post=74677"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.razib.com\/wordpress\/wp-json\/wp\/v2\/tags?post=74677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}